Derek M Yellon Selected Research

Phosphatidylinositol 3-Kinases (PI 3 Kinase)

1/2018	Ischaemic Preconditioning Protects Cardiomyocytes from Anthracycline-Induced Toxicity via the PI3K Pathway.
12/2007	Temporal changes in myocardial salvage kinases during reperfusion following ischemia: studies involving the cardioprotective adipocytokine apelin.
11/2007	Apelin-13 and apelin-36 exhibit direct cardioprotective activity against ischemia-reperfusion injury.
3/2006	Signalling via the reperfusion injury signalling kinase (RISK) pathway links closure of the mitochondrial permeability transition pore to cardioprotection.
6/2002	PI3 kinase and not p42/p44 appears to be implicated in the protection conferred by ischemic preconditioning.

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Derek M Yellon Research Topics

Disease

68	Reperfusion Injury 01/2022 - 10/2002
62	Infarction (Infarctions) 12/2022 - 06/2002
54	Myocardial Infarction 12/2022 - 03/2003
31	Ischemia 02/2016 - 08/2002
19	ST Elevation Myocardial Infarction 12/2022 - 10/2011
17	Myocardial Ischemia (Ischemic Heart Diseases) 02/2019 - 01/2005
10	Heart Failure 01/2022 - 12/2007
8	Hypoxia (Hypoxemia) 01/2017 - 07/2005
6	Type 2 Diabetes Mellitus (MODY) 01/2022 - 01/2005
6	Acute Kidney Injury (Acute Renal Failure) 08/2017 - 12/2010
6	Myocardial Reperfusion Injury 03/2016 - 09/2003
5	Cardiovascular Diseases (Cardiovascular Disease) 12/2019 - 04/2009
4	Atherosclerosis 11/2020 - 09/2009
4	Necrosis 01/2020 - 10/2002
4	Neoplasms (Cancer) 10/2018 - 02/2016
4	Obesity 05/2012 - 04/2009
4	Contracture 05/2008 - 12/2003
3	COVID-19 10/2022 - 01/2021
3	Acute Coronary Syndrome 10/2022 - 12/2011
3	Ischemic Stroke 01/2021 - 12/2019
3	Rupture 11/2020 - 01/2019
3	Heart Diseases (Heart Disease) 01/2018 - 01/2009
3	Stroke (Strokes) 02/2017 - 05/2012
3	Cardiotoxicity 02/2017 - 11/2009
3	Coronary Artery Disease (Coronary Atherosclerosis) 05/2013 - 01/2011
3	Coronary Disease (Coronary Heart Disease) 04/2009 - 04/2003
2	Inflammation (Inflammations) 01/2021 - 01/2020
2	Cardiomyopathies (Cardiomyopathy) 01/2017 - 09/2011
2	Hemorrhage 01/2017 - 10/2016
2	Metabolic Diseases (Metabolic Disease) 02/2016 - 02/2011
2	Hypertension (High Blood Pressure) 05/2012 - 08/2007
2	Acidosis 08/2010 - 09/2007
2	Body Weight (Weight, Body) 11/2009 - 01/2007

Drug/Important Bio-Agent (IBA)

26	Phosphotransferases (Kinase)IBA 01/2019 - 02/2003
15	Mitochondrial Permeability Transition PoreIBA 10/2014 - 12/2003
12	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA 10/2014 - 08/2002
9	Glucose (Dextrose)FDA LinkGeneric 01/2021 - 04/2003
8	Glucagon-Like Peptide 1 (GLP 1)IBA 01/2021 - 01/2005
7	Metformin (Glucophage)FDA LinkGeneric 01/2022 - 05/2008
6	triphenyltetrazoliumIBA 01/2019 - 02/2003
5	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 12/2022 - 12/2007
5	salicylhydroxamic acid (SHAM)IBA 11/2021 - 10/2015
5	Proteins (Proteins, Gene)FDA Link 01/2020 - 05/2010
5	Phosphatidylinositol 3-Kinases (PI 3 Kinase)IBA 01/2018 - 06/2002
5	Cyclosporine (Ciclosporin)FDA LinkGeneric 01/2017 - 08/2002
5	Insulin (Novolin)FDA Link 11/2014 - 04/2003
5	Adenosine Triphosphate (ATP)IBA 09/2007 - 08/2002
5	70-kDa Ribosomal Protein S6 Kinases (Ribosomal Protein S6 Kinases, 70 kDa)IBA 08/2007 - 09/2003
4	CytokinesIBA 10/2022 - 08/2010
4	WortmanninIBA 01/2018 - 02/2003
4	BradykininIBA 10/2017 - 02/2003
4	LipidsIBA 11/2016 - 04/2009
4	Atorvastatin (Lipitor)FDA Link 11/2011 - 02/2003
4	Erythropoietin FDA Link 10/2011 - 12/2007
4	AdipokinesIBA 03/2011 - 12/2007
4	Proto-Oncogene Proteins c-akt (Protein Kinase B)IBA 10/2010 - 02/2003
4	Protein Kinases (Protein Kinase)IBA 08/2010 - 09/2007
3	BuffersIBA 02/2019 - 06/2011
3	Evans Blue (Blue, Evans)FDA Link 01/2019 - 04/2005
3	ChemokinesIBA 01/2019 - 09/2013
3	AnthracyclinesIBA 01/2018 - 02/2016
3	AutacoidsIBA 08/2010 - 10/2003
3	Cell Surface ReceptorsIBA 07/2009 - 10/2003
3	Adenosine (Adenocard)FDA LinkGeneric 05/2009 - 09/2003
3	Phosphoric Monoester Hydrolases (Phosphatases)IBA 11/2008 - 08/2002
3	Mitogen-Activated Protein KinasesIBA 12/2007 - 01/2005
3	Diazoxide (Hyperstat)FDA Link 08/2007 - 08/2002
2	Oxygen (Dioxygen)IBA 01/2021 - 10/2017
2	Neuroprotective AgentsIBA 10/2020 - 12/2019
2	Liraglutide FDA Link 12/2019 - 02/2017
2	Sodium-Glucose Transporter 2 InhibitorsIBA 02/2019 - 02/2017
2	CXCR4 Receptors (CXCR4 Receptor)IBA 01/2019 - 09/2013
2	Caspase 1 (ICE Protease)IBA 01/2019 - 01/2018
2	Doxorubicin (Adriamycin)FDA LinkGeneric 01/2018 - 11/2009
2	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2018 - 02/2003
2	Protein Isoforms (Isoforms)IBA 10/2017 - 05/2009
2	Reactive Oxygen Species (Oxygen Radicals)IBA 02/2017 - 09/2007
2	MelatoninIBA 01/2017 - 01/2017
2	GadoliniumIBA 03/2016 - 09/2011
2	MicroRNAs (MicroRNA)IBA 02/2016 - 01/2016
2	Mitochondrial DNA (mtDNA)IBA 02/2016 - 08/2013
2	Brain Natriuretic Peptide (Natrecor)FDA Link 02/2016 - 05/2003
2	Biomarkers (Surrogate Marker)IBA 02/2016 - 01/2016
2	Troponin T (Troponin T1)IBA 10/2015 - 10/2011
2	Cyclophilins (Cyclophilin)IBA 07/2014 - 11/2011
2	Pharmaceutical PreparationsIBA 02/2013 - 01/2005
2	Peptide Hormones (Polypeptide Hormones)IBA 02/2011 - 01/2009
2	LeptinIBA 10/2010 - 04/2009
2	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 07/2009 - 02/2003
2	Purinergic P1 Receptors (Adenosine Receptor)IBA 05/2009 - 09/2003
2	UrocortinsIBA 01/2009 - 10/2002
2	Peptides (Polypeptides)IBA 01/2009 - 11/2007
2	U 0126 (UO 126)IBA 08/2008 - 09/2007

Therapy/Procedure

38	Therapeutics 01/2022 - 04/2003
19	Percutaneous Coronary Intervention 12/2022 - 11/2005
9	Ischemic Postconditioning 12/2022 - 08/2004
5	Coronary Artery Bypass (Coronary Artery Bypass Surgery) 05/2017 - 06/2010
4	Drug Therapy (Chemotherapy) 02/2017 - 06/2012
3	Length of Stay 12/2014 - 12/2010
2	Critical Care (Surgical Intensive Care) 10/2022 - 10/2022